Several amyloidoses are associated with aging, including systemic (ATTRwt, AApoAIV) and localized forms (atrial and seminal vesicle amyloid) [1]
Notes: CM = cardiomyopathy; PN = peripheral neuropathy
- Clinical manifestations are heterogeneous and may be influenced by genetic and environmental factors
- Although certain phenotypes may typically be associated with certain amyloid types, considerable clinical overlap exists and, hence, the classification of amyloidoses on clinical grounds alone is not recommended
- In clinical practice, it is critical to distinguish between treatable versus non-treatable amyloidosis
- Moreover, amyloidoses with a genetic component must be distinguished from the sporadic types and systemic amyloidoses must be distinguished from the localized forms
- Among the systemic amyloidoses, AL continues to be the most common amyloid diagnosis in the developed world; other clinically significant types include AA, ALECT2, and ATTR—which is now emerging as an underdiagnosed type in both the hereditary and wild-type setting [1]
- Picken, MM. The Pathology of Amyloidosis in Classification: A Review. Acta Haematol. 2020;143:322-334. doi: 10.1159/000506696.
